The Coimbra Group brings together nearly forty European universities and aims to influence European education and research policy, in addition to promoting research cooperation and student and academic mobility. The group emphasizes the preservation of university traditions and the promotion of academic excellence in the context of global challenges. Charles University has been a long-standing active member of this group.

Through its involvement in the Coimbra Group, CU is developing cooperation in key areas that contribute not only to the development of the academic environment but also to addressing global sustainability challenges. The Coimbra Group's annual conference was last held in Prague in 2021 and was dedicated to the topic of sustainable universities.